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The PKLR gene encodes PKL and PKR, which are expressed in the liver and erythrocytes, respectively, and the PKM gene encodes PKM1 and PKM2, both of which are expressed in various types of cells and tissues 29

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The body tightly regulates copper levels, and excess copper is normally excreted through bile

The fact that persistent inflammation can cause a neoplastic transformation to rise has contributed to understanding the interaction between HT and PTC in the past few years as shown in the Fig