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These results show that FOXO4-DRI caused nuclear exclusion of Ser15-phospho-p53 and induced apoptosis in senescent TM3 Leydig cells, and that it acted selectively against senescent cells

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The majority of musculoskeletal animal studies dose BPC-157 once daily, with regimens ranging from a single dose to daily administration for 7, 14, 28, or up to 90 days, depending on the injury model and outcome measures [20, 24, 26, 38, 60, 61]