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doi: 10.1371/JOURNAL.PPAT.1001311 158 CornellCTKiossesWBHarkinsSWhittonJL

This fasting-induced reductive redox shift in the brain may be similar to that occurring with fasting in rat liver (Williamson et al., 1967) and in human plasma and skeletal muscle ( The consequences of the fasting or DR-induced reductive shifts of the brain and liver cytoplasmic [NAD + ]/[NADH] are currently unknown