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Their formation begins when macrophages and dendritic cells recognize antigens via pattern recognition receptors (PRRs), triggering the secretion of cytokines (e.g., TNF-, IL-1, IL-6, IL-12) and chemokines (e.g., CXCL9, CXCL10, CCL2), these mediators promote macrophage recruitment and aggregation to form the granuloma core (41)

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En trminos de investigacin, el BPC 157 sirve como objeto de estudio en modelos preclnicos de reparacin de tejido blando (tendn, ligamento, msculo, hueso) y de la mucosa gastrointestinal, donde se reporta angiognesis y citoproteccin