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Need for in vivo documentations in humans The above mentioned studies are mainly based on in vitro and preclinical data, while the field would largely benefit from a more solid documentation of the capacity of riboflavin-producing organisms to increase riboflavin in vivo in humans by for example metagenomic/proteomic/metabolomic studies of the gut and vaginal microbiomes

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Signs and symptoms of overdosage reported with sulfonamides include anorexia, colic, nausea, vomiting, dizziness, headache, drowsiness and unconsciousness

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