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specific values for half-life and tissue retention vary across the literature depending on model and route of administration

10.1038/s41574-019-0156-z 16 CaniP

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Figure 8 To conclude, macrocyclizations by oxidative disulfide formations in the N-terminal of Ang IV analogues or alternatively displacement of the disulfide unite with a trans double bond can provide very potent inhibitors of IRAP, as exemplified with 23 (HA08) comprising a 13-membered ring system and 28 , 30 , and 32 comprising 14-membered ring systems