In adults, single doses above 10 grams or 150 mg/kg have a reasonable likelihood of causing toxicity.[34] Toxicity can also occur when multiple smaller doses within 24 hours exceeds these levels, or even with chronic ingestion of doses as low as 4 g/day, and death with as little as 6 g/day
Without enough, you might feel tired, weak, and have nerve problems
The published research literature has investigated: Gene expression modulation across hundreds of genes (documented in microarray studies) Collagen synthesis and skin remodeling Tissue protection through antioxidant and copper-dependent mechanisms Wound healing and dermatological research Various aging-related cellular processes The mechanisms don't overlap meaningfully
Procaccini C, Carbone F, Galgani M, La Rocca C, De Rosa V, Cassano S et al (2011) Obesity and susceptibility to autoimmune diseases
Finally, it is important to consider that next to the oxidative role of GSH, this metabolite has also shown to be a signaling agent leading to the release of GABA in retinal neurons to endorse cell protection (Freitas et al., 2017)
