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Members of the transient receptor potential C (TRPC) family of cation channels are Ca 2+ -permeable and were suggested to be involved [90]

In addition, the use of exogenous melatonin or the expression of endogenous melatonin genes could enhance the intracellular enzyme activities of catalase (CAT), peroxidase (POD), superoxide dismutase (SOD), ascorbate peroxidase (APX), and glutathione reductase (GR)

The uncontrolled generation of GSSG during oxidative stress can contribute to mitochondrial dysfunction by glutathionylation of target proteins, as described below

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Extracellular targeted protein degradation: an emerging modality for drug discovery