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In vitro angiogenesis (tube formation) assay The in vitro angiogenic activity of HUVECs (human umbilical vein endothelial cells) was determined by the Matrigel tube formation assay

Many do not, because the compound quality is unverified, the dose is based on internet research rather than clinical assessment, and there is no baseline, no follow-up, and no protocol adjustment based on individual response

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3 Clinical trials Although much of the evidence for TCM natural metabolites in CVDs comes from preclinical research, a growing number of clinical studies and trials have begun to validate their efficacy and safety in humans

Ling, C., Bacos, K