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Volumetric and thickness measurements T1-weighted anatomical images were uploaded to the volBrain online brain volumetry software ( 73 and analyzed with vol2brain 1.0, which is an online pipeline that registers images to the MNI space and reports the volumes of expert-labeled anatomical structures as a percentage of the TIV

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It's about correcting the hormonal dysregulation (leptin resistance, ghrelin elevation, insulin resistance) that keeps the body in a fat-storage state despite caloric restriction