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Targeting and modulating these circuits could therefore be the key to achieving sustainable obesity treatment

J Biol Chem 257:55795583 Sener A, Malaisse WJ (1980) L-leucine and a nonmetabolized analogue activate pancreatic islet glutamate dehydrogenase

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Because LC can impair patients' ability to work, attend school, take care of family, and care for themselves, resulting in profound emotional and physical effects on the patients, their families, and caregivers ( Cost-effective, globally available, safe, and effective therapeutic interventions are warranted to ameliorate the morbidity and mortality of LC patients