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The assay revealed however also a higher potency for SFN than for AITC, which might be due to differences in physicochemical properties such as their ability to cross the cell membrane, compound stability or differences in reactivity

Studies have reported that METH and its metabolites can induce an aberrant inflammatory response, oxidative stress, and significant DNA damage (6, 7, 8), which are correlated with severe liver pathological changes and might eventually lead to hepatic failure or cancer (9, 10)

Wilson's disease autosomal recessive copper-transport defect causing copper accumulation is the condition most often cited in community sources as a contraindication

References: [1]Tessier, Romain

Hierarchical regulatory module GENOMES UNCOUPLED1-GOLDEN2-LIKE1/2-WRKY18/40 modulates salicylic acid signaling