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The global threat of antimicrobial resistance (AMR) necessitates collaborative action to develop and implement effective strategies ( -lactamase inhibitors have been used as adjuvants for penicillin group antibiotics as they block the resistance mechanism of bacteria against these antibiotics (see Table 1)

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During the recruitment appointment and subsequent follow-up appointments at six and twelve months, the clinical status and mental health of all volunteers were evaluated, peripheral blood samples were collected, 45 plasma biomarkers (cytokines, chemokines, and growth factors) were assessed, and a comprehensive investigation was conducted using neuropsychological and ophthalmological tests, PET-CT, and magnetic resonance neuroimaging