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Open uncontrolled studies reported selected observations, but FDA found insufficient evidence of effectiveness

Lifestyle Changes In addition to diet, certain lifestyle changes can significantly impact glutathione levels: Regular exercise, which boosts the body's antioxidant defenses and stimulates glutathione production

El Mezayen et al., 2006) and intervention in the production and release of pro-inflammatory cytokines and reactive oxygen and nitrogen species (Mansour et al., 2002