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Your body may need more folate than usual if you: are pregnant have cancer have a blood disorder such as sickle cell anaemia, an inherited blood disorder that causes red blood cells to develop abnormally are fighting an infection or health condition that causes inflammation (redness and swelling) Premature babies (born before the 37th week of pregnancy) are also more likely to develop a folate deficiency because their developing bodies require higher amounts of folate than normal