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The chloroplastic isoform is likely required for the de novo methionine synthesis whereas cytosolic isoforms are most probably involved in the regeneration of Met from homocysteine (Ravanel et al., 2004)

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doi: 10.1016/j.neurobiolaging.2012.02.006

Antioxidants such as -tocopherol have not achieved the expected effects on copper-induced cell death, and the cytotoxicity of copper ion carriers may depend on copper itself [8]