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Renal Ammonia Metabolism and Transport

Some of the drugs whose plasma concentrations are reduced and/or clearance rates are increased (thus resulting in a reduced effective concentration of the drug) by consumption of St Johns wort include: alprazolam (Xanax, Xanor, Alprax, Niravam: treatment of anxiety) amitriptyline (Elavil, Tryptizol, Laroxyl, Sarotex: a tricyclic antidepressant) atorvastatin (Lipitor: treatment for hypercholesterolemia) chlorzoxazone (Paraflex, Parafon Forte, Relaxazone, Remular-S: treatment of muscle spasms) ciclosporin (Cyclosporin: immunosuppressant used by organ transplant patients) debrisoquine (a guanidine derivative for treatment of hypertension) digoxin (Lanoxin, also known as digitalis: treatment of congestive heart failure, CHF) erythromycin (E-Mycin, Eryc, Ery-Tab, PCE, Pediazole, Ilosone: antibiotic used in upper and lower respiratory infections) fexofenadine (Allegra, Telfast, Fastofen, Tilfur: antihistamine for hay fever and allergy treatment) gliclazide (Glipizide: oral type 2 diabetes drug for lowering blood glucose) imatinib (Gleevec: chemotherapeutic for Philadelphia chromosome positive chronic myelogenous leukemia) indinavir (Crixivan: a protease inhibitor used as a component of highly active antiretroviral therapy, HAART) irinotecan (Camptosar: a topoisomerase I inhibitor used as chemotherapy drug for colo-rectal cancer) ivabradine (Procoralan: management of stable angina pectoris) mephenytoin (Mesantoin: an anticonvulsant) methadone (Symoron, Dolophine, Amidone, Methadose, Physeptone, Heptadon: synthetic opioid used to treat narcotic dependence and withdrawal) midazolam (Versed, Dormicum, Hypnovel: short acting injected sleep inducer for surgery, also produces amnesia) nifedipine (Adalat, Nifedical, Procardia: treatment of hypertension) omeprazole (Prilosec, Zegerid: proton pump inhibitor used in the treatment of dyspepsia, peptic ulcer disease, PUD, and gastroesophageal reflux disorder, GERD) oral contraceptives quazepam (Doral, Dormalin: treatment of insomnia) simvastatin (Zocor: treatment for hypercholesterolemia) tacrolimus (FK-506 or Fujimycin: immunosuppressant used by organ transplant patients) verapamil (Isoptin, Verelan, Verelan PM, Calan, Bosoptin, Covera-HS: L-type calcium channel blocker for treatment of hypertension), voricoazole (VFEND: antifungal medication) warfarin (Coumadin, Jantoven, Marevan, Lawarin, Waran: anticoagulant)

doi: 10.1038/sj.cdd.4402038 85 MartinonF.BurnsK.TschoppJ

Notably, the presence of dopamine o -semiquinone is not detected by electron spin resonance [11]

Acetylcholinesterase inhibitors as Alzheimer therapy: from nerve toxins to neuroprotection