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Effects of lipoic acid on hepatic fat accumulation in diabetic rats MASLD occurs in 70%90% of cases with T2DM or IR [126]
The brain is particularly susceptible to oxidative stress due to its high oxygen demand, abundance of high-redox-active metals (such as iron and copper), and vulnerability of polyunsaturated fatty acids to oxidative damage, while the number of antioxidant factors is relatively limited [174, 175]
Mol Med Rep 11:374378 Herman RA, Veng-Pedersen P, Hoffman J, Koehnke R, Furst DE (1989) Pharmacokinetics of low-dose methotrexate in rheumatoid arthritis patients
Of 124 included subjects, 93 had complete records or could tolerate the diet for analysis
Chronic, heavy alcohol consumption can deplete the liver's glutathione stores over time, making it more vulnerable to acetaminophen-induced toxicity
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