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To investigate further, the researchers used laboratory-grown Leydig cells that were made senescent by exposure to hydrogen peroxide, mimicking the aging process

Experimental investigations show that senescent cells typically exhibit permanent cell cycle arrest mediated by p53/p21 signaling, creating a unique cellular state that depends on specific survival mechanisms for viability

Efficacy and safety of inhaled 1-antitrypsin in patients with severe 1-antitrypsin deficiency and frequent exacerbations of COPD

*Correspondence: Marc Diederich, College of Pharmacy, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, South Korea e-mail: [email protected] Michael Schnekenburger, Tommy Karius, and Marc Diederich have contributed equally to this work

Gilbert et al