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Imaging parameters Smokers smoked ad lib throughout the study and smoked a cigarette to satiety approximately 20 minutes prior to scanning sessions in order to dissipate nicotine induced vascular effects 39

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Comparison of continuous data in the IBS(+) and IBS(-) smokers There was a statistically significant age difference (p=0.03), duration of smoking (p=0.05), and FTND score (p=0.02) between patients with and without IBS