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Macrophage extracellular traps promote tumor-like biologic behaviors of fibroblast-like synoviocytes through cgas-mediated pi3k/akt signaling pathway in patients with rheumatoid arthritis

Interventions targeting this axisincluding GLP-1RAs/SGLT-2is, microbiota-directed therapy, and anti-IL-6/NLRP3 agentshold significant promise (Figure 6)

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