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They also used flow cytometry to analyse cellular damage

Since GHR expression in the kidney is unaltered in T1DM, elevated circulating GH-concentrations can impact on the kidney

Using multicellular tumor spheroids and xenograft models, they demonstrated that the cytotoxic metabolites generated from PR-104A in hypoxic tumor cells can diffuse into neighboring, less hypoxic or normoxic cells, causing significant secondary cell killing