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Causes of Budd-Chiari Syndrome Common causes Hypercoagulable states Inherited Factor V Leiden alteration Prothrombin gene alteration Acquired Myeloproliferative disorders Cancer Pregnancy Oral contraceptive use Uncommon causes Clinical Manifestations The underlying pathophysiologic abnormality in BCS is an increase in sinusoidal pressure caused by obstruction of hepatic venous outflow

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