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In addition, application of the P-15-containing graft substitutes was found to accelerate the process of early bone formation response but not the long-term effect [129, 131, 135]

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Semaglutide is FDA-approved for both type 2 diabetes (Ozempic, 2017) and chronic weight management (Wegovy, 2021), with extensive Phase 3 clinical trial data including the STEP program and SELECT cardiovascular outcomes trial (PMID: 37952131)

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Each condition requires specific dosing protocols, typically starting with frequent loading doses before transitioning to maintenance therapy

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