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10.1016/j.amjcard.2018.12.018 28

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Glutathione removes the damaged cells (which cause skin to darken) and toxins are removed from the skin and the body

The most extensively studied of these is the 677CT polymorphism in the methylenetetrahydrofolate reductase ( MTHFR ) gene, first identified in 1995 as a risk factor for vascular disease and later linked to NTDs