In diet-induced obesity animal models, NNMT inhibition demonstrated metabolic changes including alterations in adipocyte lipid content without affecting food intake patterns, coupled with significant reductions in white adipose tissue mass in treated mice
Growth factor upregulation (VEGF pathway): Also well-represented in the published literature
PKG: Protein kinase-G POD: Peroxidase PLP: Pyridoxal 5-phosphate ROS: Reactive oxygen species SAG: Senescence-activated promoter SAM: S-adenosyl-methionine SOD: Superoxide dismutase SSA: Succinic semi-aldehyde SSADH: Succinic semi-aldehyde dehydrogenase SSR: Succinic semi-aldehyde reductase References Abd Elbar OH, Elkelish A, Niedbaa G et al (2021) Protective effect of -aminobutyric acid against chilling stress during reproductive stage in tomato plants through modulation of sugar metabolism, chloroplast integrity, and antioxidative defense systems
If it helps them get more money to do research, that may be one of the reasons they do it. Sierra, for his part, admits that as much as he dislikes when Sinclair shares what he is taking, it is probably good for commercial purposes. Whether or not his personal habits have helped Sinclairs bottom line, theres no doubt hes raised a ton of funding and used it to start a slew of companies
10.3390/ijms161226225 32 DengL.HeS.GuoN.TianW.ZhangW.LuoL