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In vitro study demonstrated that a purified mitochondrial fraction from animal and human brains mainly in hippocampal neurons contains a large concentration of FOXO3 in response to epilepsy (Caballero-Caballero et al

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Toda N, Ayajiki K: Vascular actions of nitric oxide as affected by exposure to alcohol

Proteomic analysis showed that these significantly differentially expressed proteins are involved primarily in metabolic pathways including carbon metabolism, amino acid biosynthesis, pyruvate metabolism, glucagon signaling, pentose phosphate pathway, HIF-1 signaling and glycolysis/gluconeogenesis (Figure 4C)