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Knee surgery should only be tried as a last resort approach

doi: 10.4103/2230-8229.142967

Estrogen replacement enhances the expression of neurotrophic factors such as BDNF, supporting synaptic growth and neuronal survival [13]

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In experimental models, researchers may explore processes such as hypothalamicpituitary axis signaling dynamics, insulin-like growth factor-1 (IGF-1)associated pathways, and downstream metabolic signaling mechanisms