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While not the focus of this review, there is a significant body of evidence demonstrating that polymorphisms in CYP2A6, the major gene for catalysis of nicotine metabolism, have a significant effect on smoking behavior and possibly on lung cancer risk

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Table 5 shows the median total cigarette smoking prevalence in 1996 and 2012 and the annualized rate of decline in total cigarette smoking prevalence over this period among counties in each income quintile (defined in terms of income in 1996)

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