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Pathophysiology Problematic (chronic) tobacco use (eg, tobacco use disorder) involves complex physiological and psychosocial mechanisms: Physiological (ie, dependency): Nicotine strongly binds nicotinic acetylcholine receptors (nAChRs), primarily in the mesolimbic dopamine pathway

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However, it all stands the test of repeated playing, with new interpretations unfolding, always a good sign of challenging music that at the same time soothes the spirit