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10.1016/j.biopsych.2022.01.012 Biol

461,462,463,464 Notably, recent studies further support the pivotal role of NRF2 in intracellular metabolic reprogramming during hepatocyte proliferation, demonstrating its involvement in promoting glycolysis, nucleic acid synthesis, the oxidative pentose phosphate pathway (PPP), and NAD + /NADH synthesis, while downregulating OXPHOS

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Metallothionein prevents diabetes-induced cardiac pathological changes, likely via the inhibition of succinyl-CoA:3-ketoacid coenzyme A transferase-1 nitration at Trp(374)