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2,9,10 At the start of oral vitamin B12 replacement therapy, close monthly monitoring of laboratory results and symptoms is recommended, thereafter annual monitoring should suffice

There are other large RCTs where similarly high doses of vitamin B 12 have been given together with other micronutrients

As a general rule, IM is favored when the goal is rapid correction of a clinical deficiency, when the patient has difficulty absorbing B12 through oral or sublingual routes, or when a provider wants predictable peak serum levels

US National Library of Medicine

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