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Clementi A, Virz GM, Milan Manani S, Battaglia GG, Ronco C, Zanella M

After confirming their polarization into a pro-inflammatory phenotype and the enhancement of their innate functions (ROS and cytokine production), these modified macrophages were administered to mice bearing 4T1 tumors, resulting in a significant suppression of tumor growth

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626 In phase 2a, randomized, dose-finding, proof-of-concept study, NRD.E1 induced a clinically relevant pain reduction and was well tolerated