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NAC may be supportive in APD by: Helping replenish glutathione, which plays a role in regulating immune responses Reducing oxidative stress that can worsen mast cell activation and inflammation Supporting overall inflammatory balance, particularly during hormonally driven immune flares Some research also suggests NAC may influence mast cellmediated pathways indirectly 13 , which may be relevant in conditions where histamine release contributes to symptoms

Bjorvatn, B

Rotate sites systematically (abdomen, thighs, upper arms) to avoid lipohypertrophy [12]

Oxidative stress and altered antioxidant defenses in children with acute exacerbation of atopic dermatitis

If the patient is getting worse then toxicity is a concern