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Since melasma is so closely tied to hormonal fluctuations pregnancy, oral contraceptives, perimenopause addressing the hormonal component can be important

In B cells, ROS are instrumental in regulating activation 31,32 , but the contribution to B cell subsets and functions of mitochondrial ROS (mtROS), which are generated principally within mitochondria, is poorly understood

Rawat, Shalini et al (2022) RUFY1 binds Arl8b and mediates endosome-to-TGN CI-M6PR retrieval for cargo sorting to lysosomes

Besides these antioxidant defenses that ensure H 2 O 2 elimination, aquaporins have been shown to modulate mitochondrial ROS generation

Wang X, Wang D, Deng B, Yan L