glutathione synthetase inhibitor Metabolism - an overview Glutathione-Related Enzymes and Proteins: A

Adjunctive vitamin A and D during pulmonary tuberculosis treatment: a randomized controlled trial with a 2 2 factorial design

International Journal of Molecular Sciences , 19(7), 2102

Recently, it was shown that ALL subtypes are associated with differential accumulation of MTX-PG levels: ALL harboring TCF3-PBX1 or ETV6-RUNX1 fusions presented lower MTX-PG levels, whereas hyperdiploid and BCR-ABL-like ALL had higher MTX-PG levels than other subtypes (10)

These findings suggest a potential therapeutic ceiling when combining agents with overlapping mechanismsincluding natriuresis, afferent arteriolar constriction, and anti-inflammatory effectsand underscore the need for further investigation into optimal sequencing and drug combinations

FEBS J 275:39593970 Marrs KA (1996) The functions and regulation of glutathione S -transferases in plants