It may promote a brighter, more even skin tone, but results vary
The TRIUMPH-4 Phase 3 trial in obesity with knee osteoarthritis (Bays et al., NEJM 2025) reported 28.7% mean weight loss at 68 weeks at the 12 mg dose, plus a 75.8% reduction in WOMAC knee pain scores
Chae YK, Dimou A, Takahashi K, Benton CB, Jabbour E, Ravandi F, Borthakur G , Cortes JE, Kadia TM, Thomas DA, Wierda WG, Daver NG, Dinardo CD, Kantarjian HM, Garcia-Manero G
Its actions are incredibly diverse, affecting multiple pathways involved in tissue repair and remodeling
It promotes soft tissue healing by increasing the motility of repair cells and reducing inflammation through mechanisms distinct from those of penta deca peptide arginate