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Liberated Hb, however, will quickly dissociate into dimers (Vallelian et al., 2022)

Its probable mechanism includes activation of renal AGE-RAGE signaling pathways, decreasing levels of monocyte chemotactic protein-1 (MCP-1) and PKC-A, which consequently reduces the production of slit diaphragm proteins such as nephrin and podocin, thereby mitigating the impact of AGE-mediated DN pathogenesis (Muthenna et al., 2014)

A: A senolytic is a substance studied for its ability to help remove senescent cells, which are damaged cells that no longer divide but can remain active and release

Whether glutathione adds measurable benefit in this specific context remains an open question

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