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Consistently, our results showed that 25 M BPA significantly increased the levels of MDA in follicular culture medium, decreased the mitochondrial membrane potential of oocytes, the expression of antioxidant genes ( CAT, SOD1, and SOD2 ) and the anti-apoptotic gene Bcl-2 , and increased the caspase 3 and cathepsin B expression levels

Downstream targets of PPAR involved in lipid droplet formation and lipid uptake, including Cidea , Plin4 , Cidec , Cd36 , were also significantly downregulated in the livers of Gpr146 / mice (Supplementary Fig

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