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Drug-induced liver toxicity accounts for nearly half the cases of acute liver failure in adults over age 50 in the United States [3] and most have been associated with the generation of reactive metabolites, which are primarily detoxified via glutathione conjugation [4]

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6.3 Crosstalk between the glutathione and thioredoxin systems The glutathione (GSH/GR/GPx) and thioredoxin (Trx/TrxR/Prx) systems constitute the two primary thiol-based antioxidant defenses in cells

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