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Intravenous Glutathione IV glutathione carries additional risks beyond oral supplementation [60]: Skin rashes Abdominal pain Thyroid dysfunction Liver dysfunction Kidney dysfunction and possible kidney failure Stevens-Johnson syndrome (rare) These risks have been documented particularly in the context of IV glutathione used for cosmetic skin lightening, where it may be administered repeatedly at high doses (600-2,400 mg per session) [60]

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They may also reduce the effectiveness of doxycycline and minocycline, other antibiotics in the tetracycline class of antibiotics, according to StatPearls