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In KMT2A-rearranged AML, integrative multi-omics analyses identified a six-gene lactylation-associated signature (PFN1, S100A6, CBR1, LDHB, LGALS1, and PRDX1) that distinguishes this high-risk subtype from cytogenetically normal AML and associates with immune infiltration and metabolic pathway activity, defining molecular subtypes with distinct immunometabolism dependencies and suggesting potential sensitivity to PI3K, MEK, and proteasome inhibitors in signature-high cases [194]
DSIP (Delta Sleep-Inducing Peptide) DSIP is a neuropeptide that has been studied for its potential effects on sleep regulation, stress response, and neuroendocrine function
Sulforaphane suppressed tau hyper-phosphorylation and improved cognitive deficits in mouse models of AD, as well as in models of dementia-associated vascular cognitive impairment and metabolic dysfunction-driven diabetes mellitus (Hou et al., 2018
GLP-1 receptor agonists like semaglutide and tirzepatide produce the fastest visible results because they create immediate appetite suppression and large caloric deficits from the first week
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