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Untreated hypokalemia may cause respiratory paralysis, ventricular arrhythmia, and death

in which E is the expected value of the log2-normalized expression values, g 1 the inverse linkage function, 0 the intercept, j and p the coefficients for neonicotinoid (j) and DEM exposure (p), and s j and s p smooth terms for neonicotinoid (j) and DEM exposure (p) with k the basis size, respectively

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In some embodiments, the otic pharmaceutical formulation comprises about 57% by weight of the triglycerides