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0.25%) and BHA (20 M) served as controls

Homozygous and compound heterozygous mutations, as well as dominantly inherited mutations in ABCC8 / KCNJ11 cause diffuse CHI, which is often unresponsive to first line diazoxide treatment and therefore suitable for therapy with second line somatostatin receptor ligands (SRLs)

Safety Notes: Generally well-tolerated

However, currently available drugs fall short in some cases, prompting clinicians to search for therapeutic alternatives [9]

The paramagnetic probe, S-(1-oxyl-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl methanesulfonothioate (MTSL), was used to label the cysteine residue 46 of p53 TAD 67 , where 300 M MTSL-labeled p53 TAD was added to 150 M 15 N-labeled FOXO4 FHD