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Small extracellular vesicles from young plasma reverse age-related functional declines by improving mitochondrial energy metabolism

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doi: 10.1001/archopht.118.11.1556

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Notably, at physiological concentrations, TMAO can enhance the integrity of the bloodbrain barrier through the tight junction regulator annexin A1, limit the reactivity of astrocytes and microglia, and protect the cognitive function of mice from inflammatory challenges

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