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Some of the risks can be serious, such as fluid buildup in the lungs or a blood clot

61 In practice, some patients may be able to switch to very high dose (ie, 2000 mcg daily) oral supplementation instead of continuing parenteral administration, but it is impossible to predict in whom this can be done safely, and many are at risk of worsening symptoms which may become permanent

Relative telomere length and mitochondrial DNA copy number variation with age: association with plasma folate and vitamin B12. Mitochondrion 51 (2020): 79-87.

Benefits are based on preliminary research and clinical use cases

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