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Tobacco addiction is an incredibly difficult addiction for people to overcome, says Davis, the medical director for the Duke Center for Smoking Cessation at Duke University School of Medicine in Durham, North Carolina

Its simply due to repetitive exposure, Drovandi told Guardian Australia

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BPDE binds to the N2 position of guanine and causes predominantly G:C to T:A transversions and very specific chromatin hotspots for DNA mutations (see p134 Abbreviations, Definitions, and Notes section for explanations of these and other genetic terms)