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LJ-GSH initially exhibits quenched fluorescence due to the weak electron-donating effect of the thiophenol moiety, which is recovered at 815/910 nm upon activation by the overexpressed levels of glutathione (GSH) in tumor cells and tissues, significantly enhancing the specificity of tumor imaging
However, so far, no human studies have been conducted, and the issues of safety and biosafety have not been resolved (204)
Regarding the inhibitory effects of 7-nitroindazole as a selective nNOS inhibitor on scratching behavior, it seems that nNOS plays a significant role in this phenomenon