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Nicotine, which is naturally present in tobacco and added to many ENDS, is highly addictive and drives dependence, particularly among young people

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Effects of prenatal cigarette smoke exposure on BDNF, PACAP, microglia and gliosis expression in the young male mouse brainstem

Nevertheless, there is no consensus regarding the role of chronic tobacco smoking on BP

It matters most in residential and inpatient SUD settings, where admission abruptly restricts access and withdrawal symptoms (irritability, insomnia, concentration problems, craving) complicate early treatment