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Cancer Res 63 : 627635 Sciacca L, Mineo R, Pandini G, Murabito A, Vigneri R, Belfiore A (2002) In IGF-I receptor-deficient leiomyosarcoma cells autocrine IGF-II induces cell invasion and protection from apoptosis via the insulin receptor isoform A

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Moreover, the tumor microbiota is positively correlated with mitochondrial metabolic activity [87, 88], forming a microbiotametabolismimmunity axis that underpins a multidimensional resistance network and offers new insights for next-generation tumor microenvironmenttargeted strategies